Publications

Goto N, Agudo J, Yilmaz ÖH.  2025.  Early immune evasion in colorectal cancer: interplay between stem cells and the tumor microenvironment.. Trends Cancer.

Goto N, Westcott PMK, Goto S, Imada S, Taylor MS, Eng G, Braverman J, Deshpande V, Jacks T, Agudo J et al..  2024.  SOX17 enables immune evasion of early colorectal adenomas and cancers.. Nature. 627(8004):636-645.

Araki O, Tsuda M, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Yoshikawa T, Nagao M, Ogawa S et al..  2023.  Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway.. Oncogene. 42(26):2139-2152.

Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T et al..  2023.  Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis.. J Clin Invest. 133(18)

Goto N, Yilmaz ÖH.  2022.  Bispecific antibodies seek out colon cancer stem cells.. Nat Cancer. 3(4):379-380.

Nagao M, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Yoshikawa T, Ogawa S et al..  2022.  Concurrent Activation of Kras and Canonical Wnt Signaling Induces Premalignant Lesions That Progress to Extrahepatic Biliary Cancer in Mice.. Cancer Res. 82(9):1803-1817.

Yoshikawa T, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Ogawa S et al..  2022.  JNK pathway plays a critical role for expansion of human colorectal cancer in the context of BRG1 suppression.. Cancer Sci. 113(10):3417-3427.

Goto N, Goto S, Imada S, Hosseini S, Deshpande V, Yilmaz ÖH.  2022.  Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury.. Cell Stem Cell. 29(8):1246-1261.e6.

Mead BE, Hattori K, Levy L, Imada S, Goto N, Vukovic M, Sze D, Kummerlowe C, Matute JD, Duan J et al..  2022.  Screening for modulators of the cellular composition of gut epithelia via organoid models of intestinal stem cell differentiation.. Nat Biomed Eng. 6(4):476-494.

Yamada Y, Bohnenberger H, Kriegsmann M, Kriegsmann K, Sinn P, Goto N, Nakanishi Y, Seno H, Chigusa Y, Fujimoto M et al..  2022.  Tuft cell-like carcinomas: novel cancer subsets present in multiple organs sharing a unique gene expression signature.. Br J Cancer. 127(10):1876-1885.

Yoshikawa T, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Ogawa S et al..  2021.  Brg1 is required to maintain colorectal cancer stem cells.. J Pathol. 255(3):257-269.

Maruno T, Fukuda A, Goto N, Tsuda M, Ikuta K, Hiramatsu Y, Ogawa S, Nakanishi Y, Yamaga Y, Yoshioka T et al..  2021.  Visualization of stem cell activity in pancreatic cancer expansion by direct lineage tracing with live imaging.. Elife. 10

Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, Kawada K, Nagayama S, Yokoyama A, Yamamoto S et al..  2020.  Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.. Nature. 577(7789):260-265.

Ogawa S, Fukuda A, Matsumoto Y, Hanyu Y, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T et al..  2020.  SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.. Gastroenterology. 159(2):682-696.e13.

Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y et al..  2019.  Arid1a is essential for intestinal stem cells through Sox9 regulation.. Proc Natl Acad Sci U S A. 116(5):1704-1713.

Matsumoto Y, Nakanishi Y, Yoshioka T, Yamaga Y, Masuda T, Fukunaga Y, Sono M, Yoshikawa T, Nagao M, Araki O et al..  2019.  Epithelial EP4 plays an essential role in maintaining homeostasis in colon.. Sci Rep. 9(1):15244.

Goto N, Fukuda A, Yamaga Y, Yoshikawa T, Maruno T, Maekawa H, Inamoto S, Kawada K, Sakai Y, Miyoshi H et al..  2019.  Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells.. Proc Natl Acad Sci U S A. 116(26):12996-13005.

Ikuta K, Fukuda A, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Tsuda M, Kimura Y, Matsumoto Y, Kimura Y et al..  2019.  Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice.. Gut. 68(5):882-892.

Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K et al..  2018.  The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.. J Clin Invest. 128(8):3475-3489.

Yamaga Y, Fukuda A, Nakanishi Y, Goto N, Matsumoto Y, Yoshioka T, Maruno T, Chiba T, Seno H.  2018.  Gene expression profile of Dclk1+ cells in intestinal tumors.. Dig Liver Dis. 50(12):1353-1361.

Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y et al..  2018.  Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.. JCI Insight. 3(8)

Goto N, Ueo T, Fukuda A, Kawada K, Sakai Y, Miyoshi H, Taketo MMark, Chiba T, Seno H.  2017.  Distinct Roles of HES1 in Normal Stem Cells and Tumor Stem-like Cells of the Intestine.. Cancer Res. 77(13):3442-3454.

Goto N, Mimura J.  2014.  Gastrointestinal: bevacizumab-induced reversible posterior leukoencephalopathy syndrome in patient with rectal cancer.. J Gastroenterol Hepatol. 29(5):895.

Goto N, Kusaka T, Tomita Y, Tanaka H, Itokawa Y, Koshikawa Y, Yamaguchi D, Nakai Y, Fujii S, Kokuryu H.  2014.  Magnifying narrow-band imaging with acetic acid to diagnose early colorectal cancer.. World J Gastroenterol. 20(43):16306-10.

Goto N, Mimura J, Itani T, Hayashi M, Shimada Y, Matsumori T.  2012.  Autoimmune pancreatitis complicated by gastric varices: a report of 3 cases.. World J Gastroenterol. 18(31):4228-32.